WebApr 24, 2024 · Simmons notes that spiny mice appear to heal wounds incredibly quickly, which could be why they don't form much, or any, scar tissue and rather regenerate parts … WebOct 1, 2024 · Lipid overload inhibits PGC-1α by endoplasmic reticulum (ER) stress-induced CHOP. In vivo, targeting circRNA SCAR alleviates high fat diet-induced cirrhosis and insulin resistance. Clinically, circRNA SCAR is associated with steatosis-to-NASH progression. Collectively, we identify a mitochondrial circRNA that drives metaflammation and serves ...
Pericyte-derived fibrotic scarring is conserved across diverse …
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http://www.rw-designer.com/cursor-detail/2130 WebJan 30, 2024 · Unbiased transcriptomics shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury. Adoptive transfer of macrophages, from either collagen-tagged zebrafish or adult mouse GFPtpz-collagen donors, enhances scar formation via cell autonomous production of collagen. WebFeb 24, 2024 · Comparison with neonatal mouse hearts that failed to regenerate after transmural cryoinjury revealed a similar collagenolytic activity in the scar. These findings suggest that collagenolytic activity may be key to how the zebrafish heart resolves its scar; however, it is not sufficient in mouse hearts that lack efficient myocardial regeneration. osocna cuit