WebOct 21, 2016 · Koonce NA, Griffin RJ, Dings RPM: Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck … WebDec 18, 2012 · OTX008 5 μM and 10 μM improved cell viability and markedly reduced galectin-1 protein expression in cells exposed to high glucose. This was paralleled by a …
OTX-008 - National Center for Advancing Translational Sciences
WebNov 8, 2024 · While there were limited effects when OTX008 was applied alone, a strong synergism could be detected in combination with the PIK3CA inhibitor alpelisib. Indeed, previous reports directly put Gal-1 in the context of PI3K-signaling []. In our hands, alpelisib treatment increased Gal-1 expression, which might sensitize cells to OTX008 treatment. WebAug 24, 2024 · A previous study reported that LGALS1 knockdown by siRNA significantly inhibited in vitro cell proliferation in epithelial ovarian cancer. 34 SQ20B and A2780-1A9 cells treated with the LGALS1 inhibitor, OTX008, demonstrated the suppression of the ERK1/2 and AKT-dependent survival pathways to induce antiproliferative effects. 35 These results ... relational database in simple words
OTX008, a selective small-molecule inhibitor of galectin-1 ...
WebSep 1, 2014 · OTX008 enhanced the antiproliferative effects of Semaphorin-3A (Sema3A) in SQ20B cells and reversed invasion induced by exogenous Gal1. In vivo, OTX008 inhibited … WebNational Center for Biotechnology Information WebThe Safety Profile of General and Local Anaesthetic Agents: Data Collected during 20 Years of Spontaneous Reporting Activities in the Campania Region (Southern Italy) production manager kra and kpi