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Tau pathology in limbic-predominant neuronal inclusion body 4R ...

WebApr 4, 2024 · We found that 20 μM EGCG treatment for 24 hr enhanced tau exon 10 inclusion and 4R-tau expression in above differentiated human progenitor cells (Fig. 2E), supporting … Four-repeat (4R) tauopathy with neuronal and glial tau inclusions. This intronic mutation stregthens the splice acceptor site, resulting in more frequent inclusion of exon 10 into mRNA transcripts. Malkani et al., 2006; Olszewska et al., 2024: N279K: FTD : Pathogenic: Substitution: Splicing Alteration Isoform Shift; Missense: Coding : Exon 10 how many isomers exist for tif4 h2o 2

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