WebSep 21, 2015 · A rotaxane‐based Au catalyst was developed and the effect of the mechanical bond on its behavior was studied. Unlike the non‐interlocked thread, the rotaxane requires a catalytically innocent cofactor, the identity of which significantly influences both the yield and diastereoselectivity of the reaction. WebStephen Goldup’s group at the University of Southampton in the UK is well known for making mechanically-interlocked molecules, particularly rotaxanes. However, the challenge of making these molecules isn’t enough for Goldup. He is developing faster and higher yielding synthetic methods to evolve these chemical curios into molecules that ...
The active template approach to interlocked molecules
WebFeb 26, 2024 · Andrew W Heard 1 , Stephen M Goldup 1 Affiliation 1 School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom. PMID: … WebAn efficient, mild and operationally simple Ni-catalysed sp 3-carbon-to-sp 3-carbon homocoupling of unactivated alkyl bromides has been developed and utilised in the active metal template synthesis of an alkyl chain axle [2]rotaxane.The key to the transformation is the use of tridentate nitrogen-donor-atom (terpy or pybox derived) … coming home christian movie
Stephen M. Goldup - Google Scholar
WebJan 17, 2014 · E. A. Neal and S. M. Goldup, Chem. Commun., 2014, 50, 5128 DOI: 10.1039/C3CC47842D This article is licensed under a Creative Commons Attribution 3.0 Unported Licence . You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct … Web[4]Rotaxanes featuring three axles threaded through a single ring have been prepared through active metal template synthesis. Nickel-catalyzed sp3–sp3 homocouplings of alkyl bromide “half-threads” through 37- and 38-membered 2,2′:6′,2″-terpyridyl macrocycles generate triply threaded [4]rotaxanes in up to 11% yield. An analogous 39-membered … WebJan 15, 2024 · Maynard, J. R.-J.- & Goldup, S. M. Strategies for the synthesis of enantiopure mechanically chiral molecules. Chem 6 , 1914–1932 (2024). Article CAS Google Scholar dry cleaners in jamestown ny