Cyanide-catalyzed imino-stetter reaction
WebThe development of a novel protocol to access 2,2’-bisindole-3-acetic acid derivatives via the cyanide-catalyzed imino-Stetter reaction and its application to the total syntheses … WebBenzoin Condensation Stetter Reaction The Stetter Reaction is a 1,4-addition (conjugate addition) of an aldehyde to an a,β-unsaturated compound, catalyzed by cyanide or a thiazolium salt. This reaction competes with the corresponding 1,2-addition, which is the … Mechanism of Benzoin Condensation. Addition of the cyanide ion to create a …
Cyanide-catalyzed imino-stetter reaction
Did you know?
WebJun 17, 2024 · Rucaparib can be synthesized via this reaction, providing an advantageous synthetic method for the FDA-approved cancer medicine. ... -Catalyzed C–H Activation. Accounts of Chemical Research 2024, Article ASAP. Xiahong Chen, ... A cyanide-catalyzed imino-Stetter reaction enables the concise total syntheses of rucaparib. RSC … WebThe cyanide-catalyzed imino-Stetter reaction of aldimines derived from the resulting 2-aminocinnamic acid derivatives and a commercially available aldehyde afforded the desired indole-3-acetic acid derivatives. The final azepinone formation completed the total synthesis of rucaparib in 27% overall yield. To resolve the issues raised in the ...
WebAug 16, 2006 · The cyanide-catalyzed imino-Stetter reaction of aldimines derived from the resulting 2-aminocinnamic acid derivatives and a commercially available aldehyde afforded the desired indole-3-acetic ... WebThe cyanide-catalyzed imino-Stetter reaction of aldimines derived from 2-aminochalcones and aromatic aldehydes provided the corresponding 2-aryl-3-arenacylindole derivatives, which could be converted to …
WebFeb 1, 2024 · The cyanide-catalyzed imino-Stetter reaction of aldimines derived from the resulting 2-aminocinnamic acid derivatives and a commercially available aldehyde afforded the desired indole-3-acetic ... WebJul 22, 2002 · Concise Total Syntheses of Paullone and Kenpaullone via Cyanide-Catalyzed Intramolecular Imino-Stetter Reaction. S. Lee, S. Lee, C. Cheon; Chemistry. ... Cyanide-catalyzed intramolecular imino-Stetter reaction of aldimines derived from methyl 2-aminocinnamate … Expand. 10. PDF. Save.
WebThe cyanide-catalyzed imino-Stetter reaction of the resulting 2-aminocinnamonitrile and the aldehyde provides indole-3-acetonitrile with all of the desired substituents in their correct positions. The nal azepinone formation completed the synthesis of rucaparib over only three separation operations.
WebJun 2, 2024 · A new protocol for the synthesis of 2,2'-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyanide-catalyzed imino-Stetter reaction. With this protocol, the divergent total syntheses of arcyriaflavin A, a … teachers credit union plymouth indianaWebCalculated based on number of publications stored in Pure and citations from Scopus teachers credit union rio grande cityWebMay 5, 2024 · Since cyanide is also a good leaving group, it is an excellent catalyst for transacylation reactions. As an electron-withdrawing group, it also stabilizes a negative … teachers credit union rochester indianateachers credit union routingWebA Cyanide-catalyzed Imino-Stetter Reaction Enables the Concise Total Syntheses of Rucaparib Jinjae Park and Cheol-Hong Cheon* Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of ... 500 mL). The reaction mixture was stirred at 90 °C with an oil bath and monitored by TLC for 2 h. After the complete ... teachers credit union south bend hoursWebA new protocol to access benzo[a]carbazole derivatives was developed, via the cyanide-catalyzed imino-Stetter reaction/Friedel–Crafts reaction sequence.The cyanide-catalyzed imino-Stetter reaction of aldimines derived from 2-aminochalcones and aromatic aldehydes provided the corresponding 2-aryl-3-arenacylindole derivatives, … teachers credit union scherervilleWebwww.ncbi.nlm.nih.gov teachers credit union sawyer mi